If you implement responsive design then CSS's calc() is a must know feature. If you've never heard of it, here's a description from MDN:

The calc() CSS function can be used anywhere a length, frequency, angle, time, number, or integer is required. With calc(), you can perform calculations to determine CSS property values.

Mozilla Developer Network

Those who already use a pre-processor (such as Sass or LESS) and make calculations may be asking what's the difference. The answer is that with calc() you can do arithmetic with different units, including percentage values, for instance 100% - 3em.

So let’s try it. (This examples are written in SASS)

Example 1: Fixed width sidebar

You want a fixed width sidebar to the left and a fluid content to the right.

$sidebar-width: 400px

.sidebar, .content
  display: inline-block
.sidebar
  width: calc(#{$sidebar-width})
.content
  width: calc(100% - #{$sidebar-width})

The sidebar gets a fixed width and the content gets what's left from the window through calc(100% - #{$sidebar-width}).

Example 2: Equally spaced buttons

For some reason you want five buttons equally spaced. We will use two variables:

  $button-width: 4rem
  $buttons-count: 5

Then each button will be inline and have a fixed width:

button
  display: inline-block
  width: $button-width

Then all except the last button should have a right margin equal to a quarter of the remaining space:

button:not(:last-child)
  margin-right: calc((100%  - #{$button-width * $buttons-count}) / #{$buttons-count - 1})

With Flexbox you can do this even better if you don’t care for compatibility below IE 10.

Conclusion

Much can be done with this and even though there are other ways of accomplishing the same thing, I believe it is always better to make your CSS responsive and to keep your HTML clean.